U.S. officials moved this week to shut down websites owned by Canada Drugs, the Internet pharmacy and drug wholesaler that distributed counterfeit Avastin to U.S. doctors last year.

The decade-old Canada Drugs has prospered by filling millions of prescriptions for American customers with cheaper, price-controlled drugs from Canada and around the world. But the case of the fake Avastin, a cancer treatment, has ratcheted up pressure to rein in a once-bustling business of cross-border pharmaceutical sales, long opposed by the drug industry but popular with some American customers seeking discounted medicine.

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